Alexander D. Drilon: search on Z-Library

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1

NTRK fusion-positive cancers and TRK inhibitor therapy

Cocco, Emiliano, Scaltriti, Maurizio, Drilon, Alexander

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2018

Language:

english

File:

PDF, 3.46 MB

english, 2018

2

Repotrectinib (TPX-0005) is a next generation ROS1/TRK/ALK inhibitor that potently inhibits ROS1/TRK/ALK solvent front mutations

Drilon, Alexander, Ou, Sai-Hong I., Cho, Byoung Chul, Kim, Dong-Wan, Lee, Jeeyun, Lin, Jessica J., Zhu, Viola W, Ahn, Myung-Ju, Camidge, D. Ross, Nguyen, Judy, Zhai, Dayong, Deng, Wei, Huang, Zhongdon

Journal:

Cancer Discovery

Year:

2018

Language:

english

File:

PDF, 5.57 MB

english, 2018

3

Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children

Drilon, Alexander, Laetsch, Theodore W., Kummar, Shivaani, DuBois, Steven G., Lassen, Ulrik N., Demetri, George D., Nathenson, Michael, Doebele, Robert C., Farago, Anna F., Pappo, Alberto S., Turpin,

Journal:

New England Journal of Medicine

Year:

2018

Language:

english

File:

PDF, 282 KB

english, 2018

4

Pembrolizumab for the treatment of PD-L1 positive advanced or metastatic non-small cell lung cancer

Dang, Thu Oanh, Ogunniyi, Adebayo, Barbee, Meagan S., Drilon, Alexander

Journal:

Expert Review of Anticancer Therapy

Year:

2015

Language:

english

File:

PDF, 892 KB

english, 2015

5

Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1)

Drilon, Alexander, Siena, Salvatore, Ou, Sai-Hong Ignatius, Patel, Manish, Ahn, Myung Ju, Lee, Jeeyun, Bauer, Todd M., Farago, Anna F., Wheler, Jennifer J., Liu, Stephen V., Doebele, Robert, Giannetta

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 1.09 MB

english, 2017

6

A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors

Drilon, Alexander, Nagasubramanian, Ramamoorthy, Blake, James F, Ku, Nora, Tuch, Brian B., Ebata, Kevin, Smith, Steve, Lauriault, Veronique, Kolakowski, Gabrielle R, Brandhuber, Barbara J, Larsen, Pau

Journal:

Cancer Discovery

Year:

2017

Language:

english

File:

PDF, 1.43 MB

english, 2017

7

Entrectinib: an orally available, selective tyrosine kinase inhibitor for the treatment of NTRK, ROS1, and ALK fusion-positive solid tumors

Liu, Dazhi, Offin, Michael, Harnicar, Stephen, Li, Bob T., Drilon, Alexander

Journal:

Therapeutics and Clinical Risk Management

Year:

2018

Language:

english

File:

PDF, 377 KB

english, 2018

8

ALK Fusions in Renal Cell Carcinoma: Response to Entrectinib

Tao, Jessica J., Wei, Ge, Patel, Roopal, Fagan, Patrick, Hao, Xueli, Bridge, Julia A., Arcila, Maria E., Al-Ahmadie, Hikmat, Lee, Chung-Han, Li, Gary, Drilon, Alexander

Journal:

JCO Precision Oncology

Year:

2018

Language:

english

File:

PDF, 1.12 MB

english, 2018

9

Optimizing the sequencing of tyrosine kinase inhibitors (TKIs) in epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC)

Gelatti, Ana C.Z., Drilon, Alexander, Santini, Fernando C.

Journal:

Year:

2019

Language:

english

File:

PDF, 2.09 MB

english, 2019

10

ROS1-dependent cancers â biology, diagnostics and therapeutics

Drilon, Alexander, Jenkins, Chelsea, Iyer, Sudarshan, Schoenfeld, Adam, Keddy, Clare, Davare, Monika A.

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2020

File:

PDF, 3.40 MB

2020

11

Extended-Duration Therapy in Advanced Non–Small-Cell Lung Cancer: Promise and Pitfalls

Benjamin Levy, Alexander Drilon, KarLeung Siu, Michael Grossbard

Journal:

Clinical Lung Cancer

Year:

2010

Language:

english

File:

PDF, 129 KB

english, 2010

12

Squamous-cell carcinomas of the lung: emerging biology, controversies, and the promise of targeted therapy

Alexander Drilon, Natasha Rekhtman, Marc Ladanyi, Paul Paik

Journal:

The Lancet Oncology

Year:

2012

Language:

english

File:

PDF, 633 KB

english, 2012

13

Acute Promyelocytic Leukemia in HIV-Infected Adults: A Case Report and Review of Therapeutic Considerations

Alexander D. Drilon, Eric O. Gamboa, Roodabeh Koolaee, Anupama Goel

Journal:

Clinical Lymphoma Myeloma and Leukemia

Year:

2010

Language:

english

File:

PDF, 282 KB

english, 2010

14

RET Mutations in Neuroendocrine Tumors

Rudin, Charles M., Drilon, Alexander, Poirier, J. T.

Journal:

Journal of Thoracic Oncology

Year:

2014

Language:

english

File:

PDF, 189 KB

english, 2014

15

A Prospective Study of Tumor Suppressor Gene Methylation as a Prognostic Biomarker in Surgically Resected Stage I to IIIA Non–Small-Cell Lung Cancers

Drilon, Alexander, Sugita, Hirofumi, Sima, Camelia S., Zauderer, Marjorie, Rudin, Charles M., Kris, Mark G., Rusch, Valerie W., Azzoli, Christopher G.

Journal:

Journal of Thoracic Oncology

Year:

2014

Language:

english

File:

PDF, 359 KB

english, 2014

16

Acquired Resistance of EGFR- Mutant Lung Cancer to a T790M-Specific EGFR Inhibitor

Yu, Helena A., Tian, Shaozhou K., Drilon, Alexander E., Borsu, Laetitia, Riely, Gregory J., Arcila, Maria E., Ladanyi, Marc

Journal:

Year:

2015

Language:

english

File:

PDF, 253 KB

english, 2015

17

Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors

Davare, Monika A., Vellore, Nadeem A., Wagner, Jacob P., Eide, Christopher A., Goodman, James R., Drilon, Alexander, Deininger, Michael W., O’Hare, Thomas, Druker, Brian J.

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1.43 MB

english, 2015

18

From genotype to phenotype: Are there imaging characteristics associated with lung adenocarcinomas harboring RET and ROS1 rearrangements?

Plodkowski, Andrew J., Drilon, Alexander, Halpenny, Darragh F., O'Driscoll, Dearbhail, Blair, Donald, Litvak, Anya M., Zheng, Junting, Moskowitz, Chaya S., Ginsberg, Michelle S.

Journal:

Year:

2015

Language:

english

File:

PDF, 3.02 MB

english, 2015

19

Impact of Concurrent PIK3CA Mutations on Response to EGFR Tyrosine Kinase Inhibition in EGFR-Mutant Lung Cancers and on Prognosis in Oncogene-Driven Lung Adenocarcinomas

Eng, Juliana, Woo, Kaitlin M., Sima, Camelia S., Plodkowski, Andrew, Hellmann, Matthew D., Chaft, Jamie E., Kris, Mark G., Arcila, Maria E., Ladanyi, Marc, Drilon, Alexander

Journal:

Journal of Thoracic Oncology

Year:

2015

Language:

english

File:

PDF, 1.59 MB

english, 2015

20

Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung Cancer

Farago, Anna F., Le, Long P., Zheng, Zongli, Muzikansky, Alona, Drilon, Alexander, Patel, Manish, Bauer, Todd M., Liu, Stephen V., Ou, Sai-Hong I., Jackman, David, Costa, Daniel B., Multani, Pratik S.

Journal:

Journal of Thoracic Oncology

Year:

2015

Language:

english

File:

PDF, 2.09 MB

english, 2015

21

Beyond the dose-limiting toxicity period: Dermatologic adverse events of patients on phase 1 trials of the Cancer Therapeutics Evaluation Program

Drilon, Alexander, Eaton, Anne A., Schindler, Katja, Gounder, Mrinal M., Spriggs, David R., Harris, Pamela, Ivy, S. Percy, Iasonos, Alexia, Lacouture, Mario E., Hyman, David M.

Journal:

Year:

2016

Language:

english

File:

PDF, 584 KB

english, 2016

22

KRAS mutations predict sensitivity to pemetrexed-based chemotherapy

Levy, Benjamin, Drilon, Alexander, Chachoua, Abraham, Seetharamu, Nagashree, Richardson, Stacy, Lucido, David, Legasto, Alan, Grossbard, Michael, Becker, Daniel

Journal:

Lung Cancer Management

Year:

2013

Language:

english

File:

PDF, 1.19 MB

english, 2013

23

Targeting MET in Lung Cancer: Will Expectations Finally Be MET?

Drilon, Alexander, Cappuzzo, Federico, Ignatius Ou, Sai-Hong, Camidge, D. Ross

Journal:

Journal of Thoracic Oncology

Year:

2016

Language:

english

File:

PDF, 1.01 MB

english, 2016

24

The addition of anti-angiogenic tyrosine kinase inhibitors to chemotherapy for patients with advanced non-small-cell lung cancers: A meta-analysis of randomized trials

Li, Bob T., Barnes, Tristan A., Chan, David L., Naidoo, Jarushka, Lee, Adrian, Khasraw, Mustafa, Marx, Gavin M., Kris, Mark G., Clarke, Stephen J., Drilon, Alexander, Rudin, Charles M., Pavlakis, Nick

Journal:

Year:

2016

Language:

english

File:

PDF, 1.68 MB

english, 2016

25

Cabozantinib in patients with advanced RET-rearranged non-small-cell lung cancer: an open-label, single-centre, phase 2, single-arm trial

Drilon, Alexander, Rekhtman, Natasha, Arcila, Maria, Wang, Lu, Ni, Andy, Albano, Melanie, Van Voorthuysen, Martine, Somwar, Romel, Smith, Roger S, Montecalvo, Joseph, Plodkowski, Andrew, Ginsberg, Mic

Journal:

The Lancet Oncology

Year:

2016

Language:

english

File:

PDF, 353 KB

english, 2016

26

Targeted therapy outcomes in RET-rearranged lung cancers: drug or driver?

Drilon, Alexander

Journal:

The Lancet Respiratory Medicine

Year:

2016

Language:

english

File:

PDF, 89 KB

english, 2016

27

OA11.05 A Phase 2 Study of Cabozantinib for Patients with Advanced RET-Rearranged Lung Cancers

Drilon, Alexander, Somwar, Romel, Smith, Roger, Delasos, Lukas, Albano, Melanie, Van Voorthuyson, Martine, Wang, Lu, Rekhtman, Natasha, Ni, Andy, Plodkowski, Andrew, Ginsberg, Michelle, Riely, Gregory

Journal:

Journal of Thoracic Oncology

Year:

2017

Language:

english

File:

PDF, 173 KB

english, 2017

28

A phase 1b dose expansion study of the pan-class I PI3K inhibitor buparlisib (BKM120) plus carboplatin and paclitaxel in PTEN deficient tumors and with dose intensified carboplatin and paclitaxel

Smyth, Lillian M., Monson, Kelsey R., Jhaveri, Komal, Drilon, Alexander, Li, Bob T., Abida, Wassim, Iyer, Gopa, Gerecitano, John F., Gounder, Mrinal, Harding, James J., Voss, Martin H., Makker, Vicky,

Journal:

Investigational New Drugs

Year:

2017

Language:

english

File:

PDF, 323 KB

english, 2017

29

Changing the Therapeutic Landscape in Non-small Cell Lung Cancers: the Evolution of Comprehensive Molecular Profiling Improves Access to Therapy

Sabari, Joshua K., Santini, Fernando, Bergagnini, Isabella, Lai, W. Victoria, Arbour, Kathryn C., Drilon, Alexander

Journal:

Current Oncology Reports

Year:

2017

Language:

english

File:

PDF, 930 KB

english, 2017

30

O-011RET rearrangements define a new and rare molecular subtype of metastatic colorectal cancer (mCRC)

Pietrantonio, Filippo, Schrock, Alexa, Lee, Jeeyun, Drilon, Alexander, Christiansen, Jason, Chiu, Vi, Fucà, Giovanni, Morano, Federica, Rossini, Daniele, Kim Seung, Tae, Milione, Massimo, Patel, Rupal

Journal:

Annals of Oncology

Year:

2017

Language:

english

File:

PDF, 225 KB

english, 2017

31

Pan-Trk Immunohistochemistry is an Efficient and Reliable Screen for the Detection of NTRK Fusions

Hechtman, Jaclyn F., Benayed, Ryma, Hyman, David M., Drilon, Alexander, Zehir, Ahmet, Frosina, Denise, Arcila, Maria E., Dogan, Snjezana, Klimstra, David S., Ladanyi, Marc, Jungbluth, Achim A.

Journal:

American Journal of Surgical Pathology

Year:

2017

Language:

english

File:

PDF, 464 KB

english, 2017

32

Fusions in solid tumours: diagnostic strategies, targeted therapy, and acquired resistance

Schram, Alison M., Chang, Matthew T., Jonsson, Philip, Drilon, Alexander

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2017

Language:

english

File:

PDF, 2.91 MB

english, 2017

33

RASA1 and NF1 are preferentially co-mutated and define a distinct genetic subset of smokingassociated non-small cell lung carcinomas sensitive to MEK inhibition.

Hayashi, Takuo, Desmeules, Patrice, Smith, Roger S, Drilon, Alexander, Somwar, Romel, Ladanyi, Marc

Journal:

Clinical Cancer Research

Year:

2017

Language:

english

File:

PDF, 5.58 MB

english, 2017

34

Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes

Drilon, Alexander, Hu, Zishuo I., Lai, Gillianne G. Y., Tan, Daniel S. W.

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2017

Language:

english

File:

PDF, 896 KB

english, 2017

35

Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes

Drilon, Alexander, Hu, Zishuo I., Lai, Gillianne G. Y., Tan, Daniel S. W.

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2017

File:

PDF, 59 KB

2017

36

Author Correction: Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target

Cook, Peter J., Thomas, Rozario, Kannan, Ram, de Leon, Esther Sanchez, Drilon, Alexander, Rosenblum, Marc K., Scaltriti, Maurizio, Benezra, Robert, Ventura, Andrea

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 132 KB

english, 2018

37

NTRK Fusions Define a Novel Uterine Sarcoma Subtype With Features of Fibrosarcoma

Chiang, Sarah, Cotzia, Paolo, Hyman, David M., Drilon, Alexander, Tap, William D., Zhang, Lei, Hechtman, Jaclyn F., Frosina, Denise, Jungbluth, Achim A., Murali, Rajmohan, Park, Kay J., Soslow, Robert

Journal:

American Journal of Surgical Pathology

Year:

2018

Language:

english

File:

PDF, 478 KB

english, 2018

38

Unsuspected Collision of Synchronous Lung Adenocarcinomas: A Potential Cause of Aberrant Driver Mutation Profiles

Rekhtman, Natasha, Borsu, Laetitia, Reva, Boris, Arcila, Maria, Riely, Gregory J., Ladanyi, Marc, Drilon, Alexander

Journal:

Journal of Thoracic Oncology

Year:

2014

Language:

english

File:

PDF, 1.63 MB

english, 2014

39

Response to ERBB3-Directed Targeted Therapy in NRG1-Rearranged Cancers

Drilon, Alexander, Somwar, Romel, Mangatt, Biju P., Edgren, Henrik, Desmeules, Patrice, Ruusulehto, Anja, Smith, Roger S., Delasos, Lukas, Vojnic, Morana, Plodkowski, Andrew J., Sabari, Joshua, Ng, Ke

Journal:

Cancer Discovery

Year:

2018

Language:

english

File:

PDF, 3.82 MB

english, 2018

40

CT features of HER2-mutant lung adenocarcinomas

Sawan, Peter, Plodkowski, Andrew J., Li, Angela E., Li, Bob T., Drilon, Alexander, Capanu, Marinela, Ginsberg, Michelle S.

Journal:

Clinical Imaging

Year:

2018

Language:

english

File:

PDF, 1.31 MB

english, 2018

41

Immune checkpoint inhibitors plus chemotherapy versus chemotherapy or immunotherapy for first-line treatment of advanced non-small cell lung cancer: a generic protocol

Syn, Nicholas LX, Roudi, Raheleh, Wang, Louis Zizhao, Wang, Lingzhi, Loh, Marie, Huang, Yiqing, Ou, Sai-Hong Ignatius, Soong, Richie, Drilon, Alexander, Wee, Ian

Journal:

Cochrane database of systematic reviews

Year:

2018

Language:

english

File:

PDF, 409 KB

english, 2018

42

Tumor Mutation Burden and Efficacy of EGFR-Tyrosine Kinase Inhibitors in Patients with EGFR-Mutant Lung Cancers.

Offin, Michael, Rizvi, Hira, Tenet, Megan, Ni, Andy, Sanchez-Vega, Francisco, Li, Bob T., Drilon, Alexander, Kris, Mark G., Rudin, Charles M., Schultz, Nikolaus, Arcila, Maria E., Ladanyi, Marc, Riely

Journal:

Clinical Cancer Research

Year:

2018

Language:

english

File:

PDF, 2.09 MB

english, 2018

43

The activity, safety, and evolving role of brigatinib in patients with ALK-rearranged non-small cell lung cancers

Sabari, Joshua K, Santini, Fernando, Schram, Alison M, Bergagnini, Isabella, Chen, Ruqin, Mrad, Chebli, Lai, W Victoria, Arbour, Kathryn C, Drilon, Alexander

Journal:

OncoTargets and Therapy

Year:

2017

Language:

english

File:

PDF, 622 KB

english, 2017

44

Frequency of Brain Metastases and Multikinase Inhibitor Outcomes in Patients With RET–Rearranged Lung Cancers

Drilon, Alexander, Lin, Jessica J., Filleron, Thomas, Ni, Ai, Milia, Julie, Bergagnini, Isabella, Hatzoglou, Vaios, Velcheti, Vamsidhar, Offin, Michael, Li, Bob, Carbone, David P., Besse, Benjamin, Mo

Journal:

Journal of Thoracic Oncology

Year:

2018

Language:

english

File:

PDF, 585 KB

english, 2018

45

A Phase I/Ib Trial of the VEGFR-Sparing Multikinase RET Inhibitor RXDX-105

Drilon, Alexander, Fu, Siqing, Patel, Manish R., Fakih, Marwan, Wang, Ding, Olszanski, Anthony J., Morgensztern, Daniel, Liu, Stephen V., Cho, Byoung Chul, Bazhenova, Lyudmila, Rodriguez, Cristina P,

Journal:

Cancer Discovery

Year:

2018

Language:

english

File:

PDF, 3.09 MB

english, 2018

46

Expanding the Molecular Characterization of Thoracic Inflammatory Myofibroblastic Tumors beyond ALK Gene Rearrangements

Chang, Jason C., Zhang, Lei, Drilon, Alexander E., Chi, Ping, Alaggio, Rita, Borsu, Laetitia, Benayed, Ryma, Travis, William D., Ladanyi, Marc, Antonescu, Cristina R.

Journal:

Journal of Thoracic Oncology

Year:

2018

File:

PDF, 2.01 MB

2018

47

Combination MET- and EGFR-directed therapy in MET-overexpressing non-small cell lung cancers: time to move on to better biomarkers?

Santini, Fernando C., Kunte, Siddharth, Drilon, Alexander

Journal:

Translational Lung Cancer Research

Year:

2017

Language:

english

File:

PDF, 134 KB

english, 2017

48

The repertoire of genetic alterations in salivary duct carcinoma including a novel HNRNPH3-ALK rearrangement

Dogan, Snjezana, Ng, Charlotte K.Y., Xu, Bin, Kumar, Rahul, Wang, Lu, Edelweiss, Marcia, Scott, Sasinya N., Zehir, Ahmet, Drilon, Alexander, Morris, Luc G.T., Lee, Nancy Y., Antonescu, Cristina R., Ho

Journal:

Human Pathology

Year:

2019

Language:

english

File:

PDF, 14.88 MB

english, 2019

49

Learning All That We Can From MyPathway

Tao, Jessica J., Schram, Alison M., Harding, James J., Drilon, Alexander, Hyman, David M.

Journal:

Journal of Clinical Oncology

Year:

2018

Language:

english

File:

PDF, 439 KB

english, 2018

50

A Phase 1b/2 Study of Ramucirumab in Combination with Emibetuzumab in Patients with Advanced Cancer

Harding, James J, Zhu, Andrew X., Bauer, Todd M., Choueiri, Toni K., Drilon, Alexander, Voss, Martin H, Fuchs, Charles S., Abou-Alfa, Ghassan K, Wijayawardana, Sameera R, Wang, Xuejing Aimee, Moser, B

Journal:

Clinical Cancer Research

Year:

2019

Language:

english

File:

PDF, 670 KB

english, 2019

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